The Laureate Institute for Brain Research (LIBR) has recruited investigators with an impressive track record of scientific productivity to lead the three NeuroMAP projects with innovative neuroscience-based research to use individual differences on several biological levels together with sophisticated statistical approaches to generate clinically meaningful predictions of risk and outcomes for mood, anxiety, and eating disorders.
Project 1:
Modulating Repetitive Negative Thinking Related Brain Networks in Young Adults with Depression
Why It Matters:
Depression impacts approximately 11% of young adults (aged 18-25). A major challenge within this mood disorder is Repetitive Negative Thinking (RNT) - persistent negative thoughts including rumination. Unfortunately, even with available treatments, many young adults continue to struggle with these relentless negative thoughts. What We are Investigating: Our team has identified distinct neural substrates associated with RNT. We employ real-time fMRI neurofeedback (rtfMRI-nf), a novel neuroimaging technique, aiming to better understand and counteract RNT. Our Research Strategy:
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Project Outcomes:
Our long-term goal is to determine whether targeted modulation of the specific brain networks can mitigate the intensity of RNT, and consequently, alleviate the severity of depressive symptoms in young adults. Dr. Tsuchiyagaito, an Associate Investigator at LIBR, earned a Ph.D. in Child Development from Osaka University, and is a clinical psychologist with expertise in Cognitive Behavioral Therapy. Since joining LIBR in 2018, she has worked closely with Dr. Jerzy Bodurka on rtfMRI-nf applications for psychiatric disorders. As a CoBRE Research Project Leader, Dr. Tsuchiyagaito and her Research Assistant, Landon Edwards, investigate neuroscience-informed interventions for younger populations, with mentorship from Dr. Jonathan Savitz (LIBR) and Dr. Kate Fitzgerald (Columbia University/New York State Psychiatric Institute). |
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